The JNK Pathway Regulates the In Vivo Deletion of Immature CD 4 1 CD 8 1 Thymocytes

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

The extracellular signal-regulated kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and p38 MAP kinase pathways are triggered upon ligation of the antigen-specific T cell receptor (TCR). During the development of T cells in the thymus, the ERK pathway is required for differentiation of CD4(-)CD8(-) into CD4(+)CD8(+) double positive (DP) thymocytes, positive selection of DP cells, and their ma...

Commitment of Immature CD 4 1 8 1 Thymocytes to the CD 4 Lineage Requires CD 3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor ( TCR ) Chains

From the * Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892; the ‡ Howard Hughes Medical Institute and Department of Genetics and Pediatrics, The Children’s Hospital, and the Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115; and the § Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Devel...

CD 8 + to CD 4 − CD 8 − Transition from CD 4 Thymocyte Proliferation during the Early Growth Response Gene 3 Regulates

ZAP - 70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs ( ITAMs ) in Immature CD 4 1 8 1 Thymocytes with Limiting p 56 lck

As a result of interaction with epithelial cells in the thymic cortex, immature CD4 1 8 1 (double positive, DP) thymocytes express relatively few T cell receptors (TCRs) and contain diminished numbers of coreceptor-associated p56 lck (lck) PTK molecules. As a result, TCR signal transduction in DP thymocytes is significantly impaired, despite its importance for repertoire selection. We report he...

Receptor Avidity and Costimulation Specify the Intracellular Ca 2 1 Signaling Pattern in CD 4 1 CD 8 1 Thymocytes

Thymocyte maturation is governed by antigen–T cell receptor (TCR) affinity and the extent of TCR aggregation. Signals provided by coactivating molecules such as CD4 and CD28 also influence the fate of immature thymocytes. The mechanism by which differences in antigen–TCR avidity encode unique maturational responses of lymphocytes and the influence of coactivating molecules on these signaling pr...